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Vinclozolin M2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vinclozolin M2图片
CAS NO:83792-61-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Antagonist of the androgen receptor in rats
Cas No.83792-61-4
Canonical SMILESC=CC(C)(O)C(=O)Nc1cc(Cl)cc(Cl)c1
分子式C11H11Cl2NO2
分子量260.1
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:1): .5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused byB. cinerea,S. sclerotiorum, andMoniliniaspecies in grapes, fruits, vegetables, ornamental plants, and turfgrass.1Metabolites of vinclozolin, M1and M2, are effective antagonists of the androgen receptor in rats exhibiting Kivalues of 92 and 9.7 µM respectively.2In fathead minnow, M1and M2failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.3

1.Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al.Biotransformation of vinclozolin by the fungus Cunninghemella elegansJ. Agric. Food Chem.48(12)6138-6148(2000) 2.Kelce, W.R., Monosson, E., Gamcsik, M.P., et al.Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolitesToxicol. Appl. Pharmacol.126(2)276-285(1994) 3.Makynen, E.A., Kahl, M.D., Jensen, K.M., et al.Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnowAquatic Toxicology48461-475(2000)