CAS NO: | 1161070-49-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 1161070-49-0 |
别名 | 三甲胺N-氧化物 d9 |
Canonical SMILES | O=[N](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H] |
分子式 | C3D9NO |
分子量 | 84.2 |
溶解度 | Methanol: slightly soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Trimethylamine-d9N-oxide is intended for use as an internal standard for the quantification of trimethylamine N-oxide by GC- or LC-MS. Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine .1It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver.1,2,3Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-proneApoE-/-mice.1,4Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis.1,2Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.4 1.Tang, W.H.W., Wang, Z., Kennedy, D.J., et al.Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney diseaseCirc. Res.116(3)448-455(2015) 2.Wilson, A., Teft, W.A., Morse, B.L., et al.Trimethylamine-N-oxide: A novel biomarker for the identification of inflammatory bowel diseaseDig. Dis. Sci.60(12)3620-3630(2015) 3.Zhang, L.S., and Davies, S.S.Microbial metabolism of dietary components to bioactive metabolites: Opportunities for new therapeutic interventionsGenome Med.8(1)46(2016) 4.Wang, Z., Klipfell, E., Bennett, B.J., et al.Gut flora metabolism of phosphatidylcholine promotes cardiovascular diseaseNature472(7341)57-63(2011) |