您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Thiodiglycolic Acid-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Thiodiglycolic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiodiglycolic Acid-d4图片
CAS NO:132090-51-8
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of thiodiglycolic acid
Cas No.132090-51-8
Canonical SMILESOC(C([2H])([2H])SC([2H])([2H])C(O)=O)=O
分子式C4H2D4O4S
分子量154.2
溶解度DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thiodiglycolic acid-d4(TDGA-d4) contains four deuterium atoms at the 2, 2, 2', and 2' positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.1Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.2Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.2

1.Navratil, T., Petr, M., Senholdova, Z., et al.Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substancesPhysiol.Res.56(1)113-122(2007) 2.Cheng, Y.J., Huang, Y.F., and Ma, Y.C.Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workersJ.Occup.Environ.Med.43(11)934-938(2001)