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Theophylline-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Theophylline-d6图片
CAS NO:117490-39-8
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
茶碱-d6 (1,3-二甲基黄嘌呤-d6) 是氘标记的茶碱。茶碱是一种非选择性磷酸二酯酶 (PDE) 抑制剂、腺苷受体阻滞剂和组蛋白脱乙酰酶 (HDAC) 激活剂。
Cas No.117490-39-8
别名茶碱-D6,1,3-Dimethylxanthine-d6; Theo-24-d6
Canonical SMILESO=C1N(C([2H])([2H])[2H])C(C(N=CN2)=C2N1C([2H])([2H])[2H])=O
分子式C7H2D6N4O2
分子量186.2
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Theophylline-d6is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase (PDE; Ki= 100 µM).1It is also an adenosine A1and A2receptor antagonist (Ki= 14 µM for both).2Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine (EC40= 117 µM).3It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

1.Butcher, R.W., and Sutherland, E.W.Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urineJ. Biol. Chem.237(4)1244-1250(1962) 2.Daly, J.W., Padgett, W., Shamim, M.T., et al.1,3-Dialkyl-8-(p-sulfophenyl)xanthines: Potent water-soluble antagonists for A1- and A2-adenosine receptorsJ. Med. Chem.28(4)487-492(1985) 3.Leemans, J., Kirschvink, N., and Gustin, P.A comparison of in vitro relaxant responses to ipratropium bromide, β-adrenoceptor agonists and theophylline in feline bronchial smooth muscleVet. J.193(1)228-233(2012)