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Taurochenodeoxycholic Acid-d4(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Taurochenodeoxycholic Acid-d4(sodium salt)图片
CAS NO:2410279-85-3
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
Taurochenodeoxycholic acid-d4 (12-Deoxycholyltaurine-d4) sodium 是氘标记的 Taurochenodeoxycholic acid。
Cas No.2410279-85-3
别名牛磺酸去氧胆酸钠盐,12-Deoxycholyltaurine-d4 sodium
Canonical SMILESC[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
分子式C26H40D4NO6S.Na
分子量525.7
溶解度DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Taurochenodeoxycholic acid-d4is intended for use as an internal standard for the quantification of taurochenodeoxycholic acid by GC- or LC-MS. TCDCA is a taurine-conjugated form of the primary bile acid chenodeoxycholic acid .1Serum levels of TCDCA increase approximately 5-fold within two hours and begin to decrease within four hours during an oral lipid tolerance test in humans.2Serum levels of TCDCA are increased in patients with liver cirrhosis and may serve as a marker of disease progression.3

1.Hoffman, A.F.The continuing importance of bile acids in liver and intestinal diseaseArch. Intern. Med.159(22)2647-2658(1999) 2.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 3.Wang, X., Xie, G., Zhao, A., et al.Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosisJ. Proteome Res.15(4)1126-1134(2016)