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SHS4121705
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SHS4121705图片
CAS NO:2379550-82-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A mitochondrial uncoupler
Cas No.2379550-82-8
Canonical SMILESFC(F)(F)OC1=CC=C(NC2=NC3=NON=C3N=C2O)C=C1
分子式C11H6F3N5O3
分子量313.2
溶解度DMF: 10 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020)