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Roflumilast-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Roflumilast-d4图片
CAS NO:1398065-69-4
包装与价格：
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of roflumilast
Cas No.1398065-69-4
别名罗氟司特 d4
Canonical SMILESFC(F)OC1=C(OCC2C([2H])([2H])C2([2H])[2H])C=C(C(NC3=C(Cl)C=NC=C3Cl)=O)C=C1
分子式C17H10Cl2D4F2N2O3
分子量407.2
溶解度DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Roflumilast-d4is intended for use as an internal standard for the quantification of roflumilast by GC- or LC-MS. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50=<1 nm for both human pde4b and pde4d).1It is selective for PDE4, with IC50values against other PDE forms being greater than 10 μM.

1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004)