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PF-04937319(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04937319(hydrate)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A glucokinase activator
Canonical SMILESCN(C)C(C1=NC=C(OC2=C(C=C(C)O3)C3=CC(C(NC4=NC=C(C)N=C4)=O)=C2)C=N1)=O.O
分子式C22H20N6O4.XH2O
分子量432.4
溶解度DMSO: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-04937319 is an activator of glucokinase (EC50s = 174, 407, and 269 nM for the recombinant human, rat, and dog enzymes, respectively).1It increases glucose-induced insulin secretion in isolated rat islets when used at concentrations of 4 and 12 µM.2PF-04937319 (3-100 mg/kg) reduces postprandial plasma glucose levels in rats.

1.Petterson, J.C., Litchfield, J., Neef, N., et al.The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studiesToxicol. Pathol.42(4)696-708(2014) 2.Pffefferkorn, J.A., Guzman-Perez, A., Oates, P.J., et al.Designing glucokinase activators with reduced hypoglycemia risk: Discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitusMedchemcomm.2828-839(2011)