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Oleoyl Ethanolamide-d2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oleoyl Ethanolamide-d2图片
CAS NO:1245477-09-1
包装与价格:
包装价格(元)
100 μg电议
500 μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of oleoyl ethanolamide
Cas No.1245477-09-1
别名N-Oleoylethanolamide-d2; Oleamide MEA-d2; Oleic acid monoethanolamide-d2
Canonical SMILESCCCCCCCC([2H])([2H])/C=C\CCCCCCCC(N([H])CCO)=O
分子式C20H37D2NO2
分子量327.5
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): .15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oleoyl ethanolamide-d2(OEA-d2) contains two deuterium atoms at the 11 position. It is intended for use as an internal standard for the quantification of OEA by GC-or LC-mass spectrometry. OEA is an analogue of the endocannabinoid arachidonoyl ethanolamide (AEA) found in brain tissue and in chocolate.1It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2but its biosynthesis is reduced in the intestine of rats following food deprivation.3OEA is an endogenous, potent agonist for peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC50value of 120 nM in a transactivation assay.4Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.3,4These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.

1.di Tomaso, E., Beltramo, M., and Piomelli, D.Brain cannabinoids in chocolateNature382677-678(1996) 2.Epps, D.E., Palmer, J.W., Schmid, H.H.O., et al.Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acelethanolamines, a class of lipids synthesized in ischemic heart tissueThe Journal of Biological Chemisty2571383-1392(1982) 3.de Fonseca, F.R., Navarro, M., GÓmez, R., et al.An anorexic lipid mediator regulated by feedingNature414209-212(2001) 4.Fu, J., Gaetani, S., Oveisi, F., et al.Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-αNature42590-93(2003)