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Isolithocholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Isolithocholic Acid图片
CAS NO:1534-35-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
异石胆酸（β-石胆酸）是石胆酸的异构体。
Cas No.1534-35-6
别名异石胆酸,isoLCA
化学名(3β,5β)-3-hydroxy-cholan-24-oic acid
Canonical SMILESC[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C24H40O3
分子量376.6
溶解度Chloroform: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid or lithocholic acid 3α-sulfate .[1],[2] Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%.[3] Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.[4]

Reference:
[1].Batta, A.K., Salen, G., and Shefer, S.Transformation of bile acids into iso-bile acids by Clostridium perfringes: Possible transport of 3β-hydrogen via the coenzymeHepatology5(6)1126-1131(1985)
[2].Borriello, S.P., and Owen, R.W.The metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacteriaLipids17(7)477-482(1982)
[3].Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017)
[4].Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)