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Glycoursodeoxycholic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycoursodeoxycholic Acid-d4图片
CAS NO:2044276-17-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A quantitative analytical standard guaranteed to meet MaxSpec®identity, purity, stability, and concentration specifications
Cas No.2044276-17-5
别名甘氨熊去氧胆酸 d4
Canonical SMILESC[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C26H39D4NO5
分子量453.7
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycoursodeoxycholic acid-d4(GUDCA-d4) is intended for use as an internal standard for the quantification of GUDCA by GC- or LC-MS. GUDCA is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid .1,2It has antioxidant effectsin vitroin Barrett's esophagus cells and primary cultured rat neurons.3,4GUDCA reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia.5Oral administration of GUDCA (500 mg/kg per day) decreases the severity of symptoms and increases the amount ofA. muciniphila, a commensal bacterial species commonly decreased in patients with inflammatory bowel disease (IBD), in a mouse model of colitis.2

1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Van den Bossche, L., Hindryckx, P., Devisscher, L., et al.Ursodeoxycholic acid and its taurine- or glycine-conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in miceAppl. Environ. Microbiol.83(7)e02766-02716(2017) 3.Goldman, A., Condon, A., Adler, E., et al.Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cellsDis. Esophagus23(2)83-93(2010) 4.Brito, M.A., Lima, S., Fernandes, A., et al.Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acidNeurotoxicology29(2)259-269(2008) 5.Fernandes, A., Vaz, A.R., Falcao, A.S., et al.Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubinJ. Neuropathol. Exp. Neurol.66(9)789-798(2007)