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Glycodeoxycholic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycodeoxycholic Acid-d4图片
CAS NO:1069132-37-1
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
Glycodeoxycholic acid-d4 是氘标记的 Glycodeoxycholic Acid。
Cas No.1069132-37-1
别名甘氨脱氧胆酸 d4
Canonical SMILESC[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
分子式C26H39D4NO5
分子量453.7
溶解度Ethanol: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycodeoxycholic acid-d4is intended for use as an internal standard for the quantification of glycodeoxycholic acid by GC- or LC-MS. Glycodeoxycholic acid (GDCA) is a glycine-conjugated form of the secondary bile acid deoxycholic acid .1It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.2,3Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.4GDCA levels are also increased in the plasma of patients with asthma.5

1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Khurana, S., Raina, H., Pappas, V., et al.Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteriesPLoS One7(2)e32006(2012) 3.Shang, Q., Guo, G.L., Honda, A., et al.Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbitsAm. J. Physiol. Gastrointest. Liver Physiol.307(4)G479-G486(2014) 4.Woolbright, B.L., McGill, M.R., Staggs, V.S., et al.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patientsToxicol. Sci.142(2)436-444(2014) 5.Comhair, S.A.A., McDunn, J., Bennett, C., et al.Metabolomic endotype of asthmaJ. Immunol.195(2)643-650(2015)