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Glipizide-d11
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glipizide-d11图片
CAS NO:1189426-07-0
包装与价格：
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of glipizide
Cas No.1189426-07-0
别名格列吡嗪 d11
Canonical SMILESCC1=CN=C(C(NCCC2=CC=C(S(NC(NC3([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])=O)(=O)=O)C=C2)=O)C=N1
分子式C21H16D11N5O4S
分子量456.6
溶解度DMSO: slightly soluble,Ethyl Acetate: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glipizide-d11is intended for use as an internal standard for the quantification of glipizide by GC- or LC-MS. Glipizide is a hypoglycemic agent.1It inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells (IC50= 6.4 nM). Glipizide induces insulin release from isolated rat pancreatic tissue with an EC50value of 40 nM.2Dietary administration of glipizide (5 mg/kg per day for 10 days) increases the number of insulin receptors on isolated and purified mouse liver plasma membranes.3It reduces plasma glucose and triglyceride, but not total cholesterol, levels and increases plasma insulin levels in a rat model of diabetes induced by a high-fat diet and streptozotocin when administered orally at a dose of 5 mg/kg.4Formulations containing glipizide have been used in the treatment of type 2 diabetes.

1.ZÜnkler, B.J., Lenzen, S., MÄnner, K., et al.Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cellsNaunyn-Schmiedebergs Arch. Pharmacol.337(2)225-230(1998) 2.Herchuelz, A., and Malaisse, W.J.Insulinotropic potency of glipizide in vitroDiabetologia309-310(1973) 3.Feinglos, M.N., and Lebovitz, H.E.Sulphonylureas increase the number of insulin receptorsNature276(5684)184-185(1978) 4.Srinivasan, K., Viswanad, B., Asrat, L., et al.Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screeningPharmacol. Res.52(4)313-320(2005)