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CE-245677
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CE-245677图片
CAS NO:717899-97-3
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
CE-245677是一种有效的,可逆的Tie2和TrkA/B抑制剂,在细胞体系下,IC50值分别为4.7和1nM。
Cas No.717899-97-3
Canonical SMILESO=C(NC1=CC=C(Cl)C=C1Cl)NC2=CC(C(C3=CN(C(C)C)C4=NC=NC(N)=C43)=O)=CC=C2OC
分子式C24H22Cl2N6O3
分子量513.38
溶解度DMSO: 125 mg/mL (243.48 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].

CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].

[1]. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.