您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CDK4/6-IN-3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CDK4/6-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDK4/6-IN-3图片
CAS NO:2366237-37-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CDK4/6-IN-3 是一种脑渗透性的 CDK4/CDK6 抑制剂,Ki 分别为<0.3 nM 和 2.2 nM。CDK4/6-IN-3 抑制 CDK1,Ki 为 110 nM。CDK4/6-IN-3 可用于治疗胶质母细胞瘤。
Cas No.2366237-37-6
Canonical SMILESFC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5
分子式C25H31FN8
分子量462.57
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of<0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. CDK4|0.3 nM (Ki)|CDK6|2.2 nM (Ki)|CDK1|110 nM (Ki)

CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].

[1]. Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301.