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ACX-362E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACX-362E图片
CAS NO:1275582-97-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ACX-362E (ACX-362E) 是一流的、具有口服活性的 DNA 聚合酶 IIIC (pol IIIC) 抑制剂,Ki 为 0.325 μM 用于来自 C 的 DNA pol IIIC。
Cas No.1275582-97-2
别名ACX-362E; GLS-362E
Canonical SMILESO=C1NC(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N(CCN4CCOCC4)C=N3
分子式C18H20Cl2N6O2
分子量423.3
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1]. MIC50: 2 μg/mL (C. difficile)[1]

[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.