CAS NO: | 574-25-4 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
Cas No. | 574-25-4 |
别名 | 6-疏基嘌呤核苷,6TI; 6-Mercaptopurine riboside |
Canonical SMILES | S=C1NC=NC2=C1N=CN2C3[C@@H]([C@@H]([C@@H](CO)O3)O)O |
分子式 | C10H12N4O4S |
分子量 | 284.29 |
溶解度 | DMSO: 50 mg/mL (175.88 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | 6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2]. [1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105. |