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HSGN-218
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HSGN-218图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A gut-restrictive antibiotic
Canonical SMILESClC1=CC(Cl)=CC(C2=NN=C(NC(C3=CC=C(SC(F)(F)F)C=C3)=O)O2)=C1
分子式C16H8Cl2F3N3O2S
分子量434.2
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HSGN-218 is a gut-restrictive antibiotic.1It is active againstC. difficile(MIC = 0.007 µg/ml) and clinical isolates ofC. difficile(MICs = 0.003-0.03 µg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 µg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice fromC. difficilerecurrence in mouse models ofC. difficileinfection.

1.Naclerio, G.A., Abutaleb, N.S., Li, D., et al.Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivoJ. Med. Chem.63(20)11934-11944(2020)