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3-Oxobetulin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Oxobetulin图片
CAS NO:7020-34-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
3-Oxobetulin 是一种抗真菌剂,对白腐真菌 L. 显示出抗真菌活性。
Cas No.7020-34-0
Canonical SMILESC[C@]1([C@]2([C@]([C@@]3([C@@](C(C)(C(CC3)=O)C)([H])CC2)C)([H])CC4)C)[C@@]4([H])[C@]([C@@H](CC5)C(C)=C)([H])[C@@]5(CO)CC1
分子式C30H48O2
分子量440.7
溶解度DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

3-Oxobetulin is a pentacyclic triterpenoid and derivative of betulinic acid that has been found inI. macropodaand has diverse biological activities.1,2,3It is active against the plant pathogenic fungiL. betulinaandL. sulphureuswhen used at a concentration of 30 µg/ml.23-Oxobetulin reduces HIV-1 replication in MT-2 cells (IC50= 4.1 µM) with a 50% cytotoxic concentration (CC50) value of greater than 100 µM.4It inhibits cadmium-induced cytotoxicity in HepG2 cells in a concentration-dependent manner.3

1.Kim, D.K., Nam, I.Y., Kim, J.W., et al.Pentacyclic triterpenoids from Ilex macropodaArch. Pharm. Res.25(5)617-620(2002) 2.Chien, S.-C., Xiao, J.-H., Tseng, Y.-H., et al.Composition and antifungal activity of balsam from Liquidambar formosana HanceHolzforschung67(3)345-351(2013) 3.Hiroya, K., Takahashi, T., Miura, N., et al.Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmiumBioorg. Med. Chem.10(10)3229-3236(2002) 4.Callies, O., Bedoya, L.M., BeltrÁn, M., et al.Isolation, structural modification, and HIV inhibition of pentacyclic lupane-type triterpenoids from Cassine xylocarpa and Maytenus cuzcoinaJ. Nat. Prod.78(5)1045-1055(2015)