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GC376(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GC376(sodium salt)图片
CAS NO:1416992-39-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
An inhibitor of 3C- and 3C-like proteases
Cas No.1416992-39-6
Canonical SMILESOC([C@H](CC1C(NCC1)=O)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)S([O-])(=O)=O.[Na+]
分子式C21H30N3O8S•Na
分子量507.5
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GC376 is an inhibitor of 3C- and 3C-like proteases.1It inhibits recombinant poliovirus, foot and mouth disease virus (FMDV), and human rhinovirus (HRV) 3C proteases (IC50s = 1.77, 1.16, and 0.2 µM, respectively). GC376 also inhibits recombinant Norwalk virus, MD145 virus, transmissible gastroenteritis virus (TGEV), and severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteases (IC50s = 0.49, 0.96, 0.82 and 4.35 µM, respectively). It reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50= 3.37 µM).2GC376 also reduces liver viral titers by 9.86- and 21.99-fold in a model of murine hepatitis virus (MHV A59) infection when administered at doses of 50 and 100 mg/kg per day, respectively.3

1.Kim, Y., Lovell, S., Tiew, K.-C., et al.Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronavirusesJ. Virol.86(21)11754-11762(2012) 2.Ma, C., Sacco, M.D., Hurst, B., et al.Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res.30(8)678-692(2020) 3.Kim, Y., Shivanna, V., Narayanan, S., et al.Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline calicivirusesJ. Virol.89(9)4942-4950(2015)