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IMP-1700
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IMP-1700图片
CAS NO:1458674-25-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An inhibitor of bacterial DNA repair
Cas No.1458674-25-3
Canonical SMILESO=C(C1=CN(C2CC2)C3=CC(N4CCN(CC4)C(NC5=CC=C(C(F)(F)F)C=C5)=S)=C(C=C3C1=O)F)OO=C(C1=CN(C2CC2)C3=CC(N4CCN(CC4)C(NC5=CC=C(C(F)(F)F)C=C5)=S)=C(C=C3C1=O)F)O
分子式C25H22F4N4O3S
分子量534.5
溶解度DMF: slightly soluble,DMSO: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active againstE. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively).

1.Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al.Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureusBioorg. Med. Chem.27(20)114962(2019)