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DAPTA(acetate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DAPTA(acetate)图片
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A CCR5 receptor antagonist
Canonical SMILESOC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](CC(N)=O)NC([C@H]([C@H](O)C)NC([C@H]([C@H](O)C)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H](N)C)=O)=O)=O)=O)=O)=O.CC(O)=O
分子式C35H56N10O15•XC2H4O2
分子量856.9
溶解度DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DAPTA is a peptide antagonist of chemokine (C-C motif) receptor 5 (CCR5).1It inhibits CD4-dependent binding of HIV-1Ba-Land HIV-1CM235gp120 envelope proteins to CCR5 (IC50s = 0.06 and 0.32 nM, respectively). DAPTA (0.1 mg/kg, i.p.) reduces marble burying and repetitive behavior, as well as decreases brain levels of IL-6, IL-9, and IL-17A, in the BTBR T+Itpr3tf/J mouse model of autism spectrum disorder (ASD).2It also reduces LPS-induced microglial activation and astrocyte hypertrophy in the dentate gyrus in a rat model of chronic neuroinflammation.3

1.Polianova, M.T., Ruscetti, F.W., Pert, C.B., et al.Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)Antiviral Res.67(2)83-92(2005) 2.Ahmad, S.F., Ansari, M.A., Nadeem, A., et al.DAPTA, a C-C chemokine receptor 5 (CCR5) antagonist attenuates immune aberrations by downregulating Th9/Th17 immune responses in BTBR T + Itpr3tf/J miceEur. J. Pharmacol.846100-108(2019) 3.Rosi, S., Pert, C.B., Ruff, M.R., et al.Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's diseaseNeuroscience134(2)671-676(2005)