您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Vapendavir
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Vapendavir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vapendavir图片
CAS NO:439085-51-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Vapendavir (BTA798) 是一种有效的肠病毒衣壳结合剂 (CB)。
Cas No.439085-51-5
别名3-乙氧基-6-(2-(1-(6-甲基哒嗪-3-基)哌啶-4-基)乙氧基)苯并[D]异恶唑,BTA798
Canonical SMILESCCOC1=NOC2=CC(OCCC3CCN(C4=CC=C(C)N=N4)CC3)=CC=C21
分子式C21H26N4O3
分子量382.5
溶解度Chloroform: 10 mg/ml,DMF: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Vapendavir is a capsid-binding antiviral agent.1,2It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50= 7.3 ng/ml).1Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50value of 0.7 μM.2

1.Feil, S.C., Hamilton, S., Krippner, G.Y., et al.An orally available 3-ethoxybenzisoxazole capsid binder with clinical activity against human rhinovirusACS Med. Chem. Lett.3(4)303-307(2012) 2.Tijsma, A., Franco, D., Tucker, S., et al.The capsid binder vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replicationAntimicrob. Agents Chemother.58(11)6990-6992(2014)