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Rifaximin-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rifaximin-d6图片
CAS NO:1262992-43-7
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
利福昔明-d6 是氘标记的利福昔明。
Cas No.1262992-43-7
别名利福昔明-D6
Canonical SMILESOC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@](C2=O)(C)O3)=O)C4=C(N=C5N4C([2H])=C([2H])C(C([2H])([2H])[2H])=C5[2H])C6=C2C3=C(C)C(O)=C61
分子式C43H45D6N3O11
分子量791.9
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rifaximin-d6is intended for use as an internal standard for the quantification of rifaximin by GC- or LC-MS. Rifaximin is an antibiotic derived from rifamycin SV that inhibits the growth of a variety of Gram-positive and Gram-negative bacteriain vitro, includingStaphylococcus,Streptococcus,Enterococcus,H. influenzae, andN. gonorrhoeae(MIC50s = ≤0.015,<0.12, 0.25-2, 0.25, and 0.25 μg/mL, respectively).1It is a pregnane X receptor (PXR) agonist (EC50= ~20 μM) that reduces colonic damage, rectal bleeding, and diarrhea in PXR-humanized, but not wild-type orPxr-null, mice with inflammatory bowel disease (IBD) induced by dextran sulfate sodium .2,3Rifaximin exhibits minimal intestinal absorption after oral administration and is, therefore, effective in eliminating bacteria in the gastrointestinal system.4,5Formulations containing rifaximin have been used in the treatment of traveler's diarrhea caused by noninvasiveE. coli, irritable bowel syndrome with diarrhea (IBS-D), and to reduce the risk of recurrence of overt hepatic encephalopathy.

1.Hoover, W.W., Gerlach, E.H., Hoban, D.J., et al.Antimicrobial activity and spectrum of rifaximin, a new topical rifamycin derivativeDiagn. Microbiol. Infect. Dis.16(2)111-118(1993) 2.Ma, X., Shah, Y.M., Guo, G.J., et al.Rifaximin is a gut-specific human pregnane X receptor activatorJ. Pharmacol. Exp. Ther.322(1)391-398(2007) 3.Cheng, J., Shah, Y.M., Ma, X., et al.Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activationJ. Pharmacol. Exp. Ther.335(1)32-41(2010) 4.Alajbegovic, S., Sanders, J.W., Atherly, D.E., et al.Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): A systematic review and meta-analysisSyst. Rev.1:39(2012) 5.Song, M., and Ang, T.L.Second and third line treatment options for Helicobacter pylori eradicationWorld J. Gastroenterol.20(6)1517-1528(2014)