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Nevirapine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nevirapine-d4图片
CAS NO:1051418-95-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
奈韦拉平-D4 是氘标记的奈韦拉平。
Cas No.1051418-95-1
别名奈韦拉平 D4
Canonical SMILESO=C1C2=C(N=CC=C2)N(C3C([2H])([2H])C3([2H])[2H])C4=C(C(C)=CC=N4)N1
分子式C15H10D4N4O
分子量270.3
溶解度DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 2.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nevirapine-d4is intended for use as an internal standard for the quantification of nevirapine by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).1It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50= 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.2Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.

1.Grobler, J.A., Dornadula, G., Rice, M.R., et al.HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitroJ. Biol. Chem.282(11)8005-8010(2007) 2.Grob, P.M., Cao, Y., Muchmore, E., et al.Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptaseNat. Med.3(6)665-670(1997)