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MPro Inhibitor 11a
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MPro Inhibitor 11a图片
CAS NO:2103278-86-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of SARS-CoV-2 Mpro
Cas No.2103278-86-8
Canonical SMILESO=C1NCC[C@H]1C[C@H](NC([C@@H](NC(C2=CC(C=CC=C3)=C3N2)=O)CC4CCCCC4)=O)C=O
分子式C25H32N4O4
分子量452.6
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 µM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.53 µM). MProinhibitor 11a also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 µM.

1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main proteaseScience368(6497)1331-1335(2020)