CAS NO: | 1346598-58-0 |
包装: | 1mg |
市场价: | 2250元 |
Cas No. | 1346598-58-0 |
别名 | 爱莎康唑-D4,BAL-4815-d4; RO-0094815-d4 |
Canonical SMILES | FC(C=CC(F)=C1)=C1[C@](CN2N=CN=C2)(O)[C@@H](C)C3=NC(C4=C([2H])C([2H])=C(C#N)C([2H])=C4[2H])=CS3 |
分子式 | C22H13D4F2N5OS |
分子量 | 441.5 |
溶解度 | Acetonitrile: soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Isavuconazole-d4is intended for use as an internal standard for the quantification of isavuconazole by GC- or LC-MS. Isavuconazole is a broad-spectrum triazole antifungal agent.1It inhibits the growth of clinical isolates ofA. fumigatus,A. terreus,A. flavus, andA. lentulus(MIC90s = 0.39, 0.39, 2, and 0.25 mg/L, respectively) as well asC. albicans,C. krusei, andC. parapsilosis(MIC50s = 0.03, 0.06, and 0.03 mg/L, respectively).1,2,3,4Isavuconazole also inhibits the growth of several other fungal species, including clinical isolates ofC. neoformansandC. gattii(MIC90s = 0.032 and 0.125 mg/L, respectively).1,3Formulations containing isavuconazole have been used in the treatment of invasive aspergillosis and mucormycosis. 1.Yamazaki, T., Inagaki, Y., Fujii, T., et al.In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from JapanInt. J. Antimicrob. Agents36(4)324-331(2010) 2.Rudramurthy, S.M., Chakrabarti, A., Geertsen, E., et al.In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: Assessment according to the methodology of the European Committee on Antimicrobial Susceptibility TestingDiagn. Microbiol. Infect. Dis.71(4)370-377(2011) 3.Datta, K., Rhee, P., Byrnes, E., III, et al.Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibilityJ. Clin. Microbiol.51(9)3090-3093(2013) 4.Astvad, K.M.T., Hare, R.K., and Arendrup, M.C.Evaluation of the in vitro activity of isavuconazole and comparator voriconazole against 2635 contemporary clinical Candida and Aspergillus isolatesClin. Microbiol. Infect.23(11)882-887(2017) |