Globosuxanthone A 是一种二氢蒽酮，对禾谷镰刀菌、茄病镰刀菌和灰霉病菌具有明显的抗真菌活性，MIC 值分别为 4、8 和 16 μg/mL。
| Cas No. | 917091-74-8 |
| Canonical SMILES | OC1=C2C(OC(C=C[C@@H](O)[C@@]3(O)C(OC)=O)=C3C2=O)=CC=C1 |
| 分子式 | C15H12O7 |
| 分子量 | 304.3 |
| 溶解度 | DMSO: Soluble,Ethanol: 1 mg/ml,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Globosuxanthone A is a fungal metabolite originally isolated from C. globosum. It is cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 µM, respectively). It induces accumulation of cells in the G2/M and S phases of the cell cycle in NCI-H460 and PC3M cells. Globosuxanthone A is also active against C. albicans but not S. aureus, E. coli, or M. hiemalis. |
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