Allethrin 是一种拟除虫菊酯类杀虫剂,是一种主要的驱蚊剂。 Allethrin 在大鼠睾丸癌细胞 (LC540) 中诱导氧化应激、细胞凋亡和钙释放。 Allethrin 诱导 BCL-2、caspase-3 活化和细胞内钙的释放。
Cas No. | 584-79-2 |
别名 | 丙烯菊酯 |
Canonical SMILES | C/C(C)=C/C1C(C)(C)C1C(OC2C(C)=C(CC=C)C(C2)=O)=O |
分子式 | C19H26O3 |
分子量 | 302.4 |
溶解度 | Chloroform: Slightly Soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV). It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes. It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%). Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells. In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice. |