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12(S)-HETE
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
12(S)-HETE图片
CAS NO:54397-83-0
包装与价格：
包装价格(元)
25μg电议
50μg电议
100μg电议

产品介绍
Cas No.54397-83-0
化学名12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Canonical SMILESCCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
分子式C20H32O3
分子量320.5
溶解度<0.1 M Na2CO3: 2 mg/ml; PBS pH 7.2: 0.8 mg/ml; Miscible in DMF; Miscible in DMSO; Miscible in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. [1] It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1μM181M.[2][3]

Reference:
[1]. Hamberg, M., and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. U.S.A. 71(9), 3400-3404 (1974).
[2]. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res. 49(4), 1029-1037 (1989).
[3]. Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44(5), 413-429 (1992).