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Calmidazolium chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calmidazolium chloride图片
CAS NO:57265-65-3
包装:10mg
市场价:900元

产品介绍
Calmidazolium chloride (R 24571) 是一种钙调蛋白 (CaMK) 拮抗剂,可拮抗 CaM 依赖性磷酸二酯酶和钙调素诱导的红细胞 Ca2 激活+-转运 ATP 酶的 IC50 值分别为 0.15 和 0.35 μM。
Cas No.57265-65-3
别名钙调蛋白抑制剂,R 24571
化学名(S)-1-(bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride
Canonical SMILESClC1=CC(Cl)=CC=C1[C@@H](C[N+]2=CN(C=C2)C(C(C=C3)=CC=C3Cl)C(C=C4)=CC=C4Cl)OCC(C(Cl)=C5)=CC=C5Cl.[Cl-]
分子式C31H23Cl7N2O
分子量687.7
溶解度100mM in ethanol, or in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 μM, respectively).[1] Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 μM, respectively).[1] It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 μM).[2],[3]

Reference:
[1]. Gietzen, K. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochemistry Journal 216(3), 611-616 (1983).
[2]. Harper, J.L., and Daly, J.W. Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochemical Pharmacology 60(3), 317-324 (2000).
[3]. Peppiatt, C.M., Holmes, A.M., Seo, J.T., et al. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochemistry Journal 381(3), 929-939 (2004).