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Pantoprazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pantoprazole图片
CAS NO:102625-70-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议

产品介绍
泮托拉唑 (BY10232) 是一种口服有效的质子泵抑制剂 (PPI)。
Cas No.102625-70-7
别名泮托拉唑; BY1023; SKF96022
分子式C16H15F2N3O4S
分子量383.37
溶解度≥ 17.95mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pantoprazole is an inhibitor of H+/K+-ATPase [1].

Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori [1, 2].

References:
[1] Jungnickel P W.  Pantoprazole: a new proton pump inhibitor. Clinical therapeutics, 2000, 22(11): 1268-1293.
[2] Sachs G, Shin J M, Howden C W.  Review article: the clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 2006, 23(s2): 2-8.