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Maprotiline HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maprotiline HCl图片
CAS NO:10347-81-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Maprotiline HCl 是一种选择性去甲肾上腺素再摄取抑制剂和四环类抗抑郁药。
Cas No.10347-81-6
别名盐酸马普替林
化学名3-(9,10-dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine hydrochloride
Canonical SMILESCl[H].[H]C12C([H])([H])C([H])([H])C(C3=C([H])C([H])=C([H])C([H])=C23)(C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C14
分子式C20H23N.HCl
分子量313.86
溶解度≥ 13.95mg/mL in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2].

References:
[1]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8.
[2]. http://en.wikipedia.org/wiki/Maprotiline