CAS NO: | 1630936-95-6 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 1630936-95-6 |
别名 | ML396 |
Canonical SMILES | O=C(NC1=CC(Cl)=C(OC2=CC=C(Cl)C=N2)C=C1)C3=CC=CC=N3 |
分子式 | C17H11Cl2N3O2 |
分子量 | 360.2 |
溶解度 | Chloroform: slightly soluble,DMSO: slightly soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.1 ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.2 |1. Jalan-Sakrikar, N., Field, J.R., Klar, R., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem. Neurosci. 5(12), 1221-1237 (2014).|2. Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci. Transl. Med. 9(403), (2017). |