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ML401
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML401图片
CAS NO:1597489-14-9
包装与价格:
包装价格(元)
1mg电议
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产品介绍
ML401 是一种有效的化学探针,选择性地拮抗 EBI2 (也称为 GPR183),IC50 值为1.03 nM。ML401 在趋化性分析中显示活性 (IC50=6.24 nM)。ML401 表现出良好的稳定性,且无细胞毒性。
Cas No.1597489-14-9
Canonical SMILESO=C(/C=C/C1=CC=C(C=C1)Br)N2CCN(CC2)CC3=CC=C(C=C3)Cl
分子式C20H20BrClN2O
分子量419.74
溶解度DMSO: 10.42 mg/mL (24.82 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

ML401 shows very good stability in both human plasma and mouse plasma[1].

[1]. Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet].