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AF40431
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AF40431图片
CAS NO:181125-92-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
AF40431 是首个报道的 sortilin 小分子配体,IC50 为 4.4 µM,Kd 为 0.7 µM。AF40431 结合在 sortilin 的神经降压素结合位点。
Cas No.181125-92-8
Canonical SMILESCC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O
分子式C17H21NO5
分子量319.35
溶解度DMSO: 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

[1]. Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60.