ERB 041

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ERB 041

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

524684-52-4

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

ERB 041 (ERB-041) 是一种有效的选择性雌激素受体 (ER) β；激动剂，对人、大鼠和小鼠 ERβ 的 IC50 分别为 5.4、3.1 和 3.7 nM；， ERB 041 对 ERβ 的选择性超过 200 倍；超过 ERα. ERB 041 是一种有效的皮肤癌化学预防剂，通过抑制 WNT/β-catenin 信号通路发挥作用。 ERB 041 诱导卵巢癌凋亡。

Cas No.	524684-52-4
别名	普林贝瑞; ERB-041
化学名	(Z)-2-fluoro-4-(5-hydroxy-7-vinylbenzo[d]oxazol-2(3H)-ylidene)cyclohexa-2,5-dienone
Canonical SMILES	FC1=C/C(C=CC1=O)=C(NC2=C3)\OC2=C(C=C)C=C3O
分子式	C₁₅H₁₀FNO₃
分子量	271.24
溶解度	DMSO: 25 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Prinaberel(ERB-041) is a potent and selective ERbeta agonist; being >200-fold selective for ERbeta.IC50 value:Target: ERbeta agonistin vitro: Treatment with ERβ selective estrogen agonists liquiritigenin and ERB-041 reduced the ability to invade a reconstituted basement membrane and to migrate in response to the cellular stimulus [1]. Pretreatment the PMs with ERB-041 resulted in a significant inhibition of LPS-induced iNOS expression and NF-kappaB activation by preventing its nuclear translocation [3].in vivo: Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041-treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by the decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis [2]. References: [1]. Hinsche O, et al. Estrogen receptor β selective agonists reduce invasiveness of triple-negative breast cancer cells. Int J Oncol. 2015 Feb;46(2):878-84. [2]. Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98. [3]. Xiu-li W, et al. ERB-041, a selective ER beta agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-kappaB activation. Mol Immunol. 2009 Jul;46(11-12):2413-8.