| CAS NO: | 1185247-12-4 |
| 包装: | 1mg |
| 市场价: | 4067元 |
| Cas No. | 1185247-12-4 |
| 别名 | 富马酸喹硫平 d8 (富马酸盐) |
| Canonical SMILES | OC(/C=C/C(O)=O)=O.OCCOCCN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1C2=NC(C=CC=C3)=C3SC4=C2C=CC=C4 |
| 分子式 | C21H17D8N3O2S•C4H4O4 |
| 分子量 | 507.6 |
| 溶解度 | DMF: soluble,DMSO: soluble,Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Quetiapine-d8is intended for use as an internal standard for the quantification of quetiapine by GC- or LC-MS. Quetiapine is an atypical, second generation antipsychotic compound.1,2,3It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2Cadrenergic receptors (Kis = 22, 15, and 29 nM, respectively).4,5Quetiapine also potently antagonizes the histamine H1receptor (Ki= 11 nM).5 1.Seeman, P.Atypical antipsychotics: Mechanism of actionCan. J. Psychiatry47(1)27-38(2002) 2.Rummel-Kluge, C., Komossa, K., Schwarz, S., et al.Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisonsSchizophr. Bull.38(1)167-177(2012) 3.Cerejeira, J., and Mukaetova-Ladinska, E.B.A clinical update on delirium: From early recognition to effective managementNurs. Res. Pract.875196(2011) 4.Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1)29-39(2000) 5.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003) |
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