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LY 2886721 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY 2886721 Hydrochloride图片
CAS NO:1262036-49-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Cas No.1262036-49-6
别名N-[3-[(4AS,7AS)-2-氨基-5,7-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(4AH)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺盐酸盐
Canonical SMILES[H][C@@]12COC[C@]1(C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F)N=C(SC2)N.Cl
分子式C18H16F2N4O2S.HCl
分子量426.87
溶解度DMSO|42.69|100|
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.