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Valdecoxib-d3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Valdecoxib-d3图片
CAS NO:1219794-90-7
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of valdecoxib
Cas No.1219794-90-7
别名戊地昔布-D3,SC 65872-d3
Canonical SMILES[2H]C([2H])([2H])C1=C(C2=CC=C(S(N)(=O)=O)C=C2)C(C3=CC=CC=C3)=NO1
分子式C16H11D3N2O3S
分子量317.4
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Valdecoxib-d3is intended for use as an internal standard for the quantification of valdecoxib by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM, for human recombinant COX-2 and COX-1, respectively).1It decreases LPS-induced production of prostaglandin E2in isolated human whole blood (IC50= 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).

1.Talley, J.J., Brown, D.L., Carter, J.S., et al.4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2J. Med. Chem.43(5)775-777(2000)