| CAS NO: | 1331635-21-2 |
| 包装: | 1mg |
| 市场价: | 4158元 |
| Cas No. | 1331635-21-2 |
| 别名 | 盐酸奥洛他定 d3 (盐酸盐) |
| Canonical SMILES | [2H]C([2H])([2H])N(C)CC/C=C1C2=CC(CC(O)=O)=CC=C2OCC3=CC=CC=C3/1.Cl |
| 分子式 | C21H20D3NO3.HCl |
| 分子量 | 376.9 |
| 溶解度 | Methanol: Slightly soluble,Water: Slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Olopatadine-d3is intended for use as an internal standard for the quantification of olopatadine by GC- or LC-MS. Olopatadine is a histamine H1receptor antagonist (Ki=41 nM).1It is 1,059- and 4,177-fold selective for histamine H1over H2and H3receptors, respectively. Olopatadine inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human trabecular meshwork (TM3) cells (IC50s = 9.5, 19, and 39.9 nM, respectively).In vivo, olopatadine inhibits passive cutaneous anaphylaxis in rats (ED50= 49 µg/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50= 30 µg/kg).2Formulations containing olopatadine have been used in the treatment of allergic rhinitis and conjunctivitis, as well as in the treatment of itch in patients with well-controlled urticaria. 1.Sharif, N.A., Xu, S.X., and Yanni, J.M.Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitisJ. Ocul. Pharmacol. Ther.12(4)401-407(1996) 2.Ohshima, E., Otaki, S., Sato, H., et al.Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivativesJ. Med. Chem.35(11)2074-2084(1992) |
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