| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=C3C=CC=C5)C=C2)CC1.Cl.Cl.O |
| 分子式 | C24H24N4.2HCl [XH2O] |
| 分子量 | 441.4 |
| 溶解度 | DMSO: Soluble,Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively).1It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice.2JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.3 1.Sallinen, J., HÖglund, I., EngstrÖm, M., et al.Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302Br. J. Pharmacol.150(4)391-402(2007) 2.Imaki, J., Mae, Y., Shimizu, S., et al.Therapeutic potential of α2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disordersNeurosci. Lett.454(2)143-147(2009) 3.Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I., et al.Effect of selective blockade of α?-adrenoceptor subtypes on cardiovascular system in ratsBull. Exp. Biol. Med.158(4)410-412(2015) |
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