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Arbutin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Arbutin图片
CAS NO:497-76-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
20mg电议

产品介绍
Arbutin (β-Arbutin) 是酪氨酸酶的竞争性抑制剂，单酚酶的 Kiapp 值为 1.42 mM；双酚酶为 0.9 mM。熊果苷也用作脱色剂。熊果苷是从熊果植物 Arctostaphylos uvaursi 中分离出来的一种天然多酚，具有抗氧化、抗炎和抗肿瘤的特性。
Cas No.497-76-7
别名α-熊果苷; 4-Hydroxyphenyl α-D-glucopyranoside
化学名(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
Canonical SMILESC1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O
分子式C12H16O7
分子量272.25
溶解度≥ 13.7mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner[2].Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2].

Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3].

References:
[1]. Garcia-Jimenez A, et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330.
[2]. Jiang L, et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054.
[3]. Nalban N, et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4.