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SID7970631
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SID7970631图片
CAS NO:868224-75-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
SID7970631 作为一种异喹啉酮类似物,是一种有效的、选择性的亚微摩尔 SF-1 抑制剂 (IC50=260 nM)。SID7970631可用于癌症研究。
Cas No.868224-75-3
分子式C24H24N2O7
分子量452.46
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].

SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].

[1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784.
[2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23.