| CAS NO: | 1189878-76-9 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1189878-76-9 |
| 别名 | 齐留通 d4 |
| Canonical SMILES | ON(C(N)=O)C(C([2H])([2H])[2H])([2H])C1=CC2=CC=CC=C2S1 |
| 分子式 | C11H8D4N2O2S |
| 分子量 | 240.3 |
| 溶解度 | DMSO: slightly soluble,Methanol: very slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Zileuton-d4is intended for use as an internal standard for the quantification of zileuton by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.1It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50value of 0.5 µM. Zileuton inhibits leukotriene B4production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50= 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.2Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma. 1.Carter, G.W., Young, P.R., Albert, D.H., et al.5-Lipoxygenase inhibitory activity of zileutonJ. Pharmacol. Exp. Ther.256(3)929-937(1991) 2.Abraham, W.M., Ahmed, A., Cortes, A., et al.The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheepEur. J. Pharmacol.217(2-3)119-126(1992) |
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