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Loratadine-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loratadine-d5图片
CAS NO:1020719-57-6
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of loratadine
Cas No.1020719-57-6
别名五氘代氯雷他定,Loratidine-d5; SCH 29851-d5
Canonical SMILESClC(C=C1)=CC(CC([2H])([2H])C2=C/3N=C([2H])C([2H])=C2[2H])=C1C3=C4CCN(C(OCC)=O)CC/4
分子式C22H18ClD5N2O2
分子量387.9
溶解度DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Loratadine-d5is intended for use as an internal standard for the quantification of loratadine by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1receptors (Ki= 35 nM).1,2,3It has been shown to inhibit the release of leukotriene C4(IC50= 8 µM) and histamine (IC50= 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50value of 0.40 mg/kg.4Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.

1.Ahn, H.S., and Barnett, A.Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamineEur. J. Pharmacol.127(1-2)153-155(1986) 2.Kay, G.G., and Harris, A.G.Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedationClin. Exp. Allergy29(Suppl 3)147-150(1999) 3.Barnett, A., Iorio, L.C., Kreutner, W., et al.Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents Actions43(3-4)149-156(1994) 4.Kreutner, W., Chapman, R.W., Gulbenkian, A., et al.Antiallergic activity of loratadine, a non-sedating antihistamineAllergy42(1)57-63(1987)