CAS NO: | 1020719-57-6 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 1020719-57-6 |
别名 | 五氘代氯雷他定,Loratidine-d5; SCH 29851-d5 |
Canonical SMILES | ClC(C=C1)=CC(CC([2H])([2H])C2=C/3N=C([2H])C([2H])=C2[2H])=C1C3=C4CCN(C(OCC)=O)CC/4 |
分子式 | C22H18ClD5N2O2 |
分子量 | 387.9 |
溶解度 | DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Loratadine-d5is intended for use as an internal standard for the quantification of loratadine by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1receptors (Ki= 35 nM).1,2,3It has been shown to inhibit the release of leukotriene C4(IC50= 8 µM) and histamine (IC50= 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50value of 0.40 mg/kg.4Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria. 1.Ahn, H.S., and Barnett, A.Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamineEur. J. Pharmacol.127(1-2)153-155(1986) 2.Kay, G.G., and Harris, A.G.Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedationClin. Exp. Allergy29(Suppl 3)147-150(1999) 3.Barnett, A., Iorio, L.C., Kreutner, W., et al.Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents Actions43(3-4)149-156(1994) 4.Kreutner, W., Chapman, R.W., Gulbenkian, A., et al.Antiallergic activity of loratadine, a non-sedating antihistamineAllergy42(1)57-63(1987) |