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Leukotriene E4-d5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Leukotriene E4-d5图片
CAS NO:1240398-14-4
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议

产品介绍
A quantitative analytical standard guaranteed to meet MaxSpec®identity, purity, stability, and concentration specifications
Cas No.1240398-14-4
别名LTE4-d5
Canonical SMILESO[C@H](CCCC(O)=O)[C@H](SC[C@H](N)C(O)=O)/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H]
分子式C23H32D5NO5S
分子量444.6
溶解度DMF: >50 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS (pH 7.2): >100 μg/ml
储存条件Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leukotriene E4-d5(LTE4-d5) contains five deuterium atoms at the 19, 19', 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4by GC-or LC-mass spectrometry. LTE4is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.1It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).2LTE4is considerably less active (8 to 12-fold) than LTC4in the biological activities characteristic of cysteinyl leukotrienes.1,3Unlike LTC4and LTD4, LTE4accumulates in both plasma and urine. Therefore, urinary excretion of LTE4is most often used as an indicator of asthma.4,5,6In humans, basal levels of LTE4range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4levels increase to 80-1,000 pg/mg creatinine.5

1.BernstrÖm, K., and HammarstrÖm, S.Metabolism of leukotriene D by porcine kidneyJ. Biol. Chem.256(18)9579-9582(1981) 2.Samuelsson, B.Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammationScience220(4597)568-575(1983) 3.Lefer, A.M.Leukotrienes as mediators of ischemia and shockBiochem. Pharmacol.35(2)123-127(1986) 4.Kumlin, M., Stensvad, F., Larsson, L., et al.Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humansClin. Exp. Allergy25(5)467-479(1995) 5.Drazen, J.M., O'Brien, J., Sparrow, D., et al.Recovery of leukotriene E4 from the urine of patients with airway obstructionAm. Rev. Respir. Dis.146(1)104-108(1992) 6.Kumlin, M., DahlÉn, B., BjÖrck, T., et al.Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmaticsAm. Rev. Respir. Dis.146(1)96-103(1992)