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TH34
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH34图片
CAS NO:2196203-96-8
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
TH34 是一种 HDAC6/8/10 抑制剂,IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM,对 HDAC1/2/3 具有高选择性。
Cas No.2196203-96-8
化学名3-(benzylamino)-N-hydroxy-4-methylbenzamide
Canonical SMILESO=C(NO)C1=CC=C(C)C(NCC2=CC=CC=C2)=C1
分子式C15H16N2O2
分子量256.305
溶解度DMSO : 150 mg/mL (585.25 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TH34 is a potent HDAC6/8/10 inhibitor. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. The combination of TH34 with plasma-achievable concentrations of retinoic acid, a drug applied in neuroblastoma therapy, synergistically inhibits colony growth (combination index (CI) < 0.1 for 10 μM of each). In summary, our study supports using selective HDAC inhibitors as targeted antineoplastic agents and underlines the therapeutic potential of selective HDAC6/8/10 inhibition in high-grade neuroblastoma.

Reference

[1].Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W, Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi: 10.1007/s00204-018-2234-8. Epub 2018 Jun 9. PubMed PMID: 29947893; PubMed Central
PMCID: PMC6063332.