Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.^1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P₁, S1P₂, and S1P₃(EC₅₀s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).³It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC₅₀= ~35 nM).⁴Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.^2,5L-threolysosphingomyelin is also an S1P_1-3agonist (EC₅₀s = 19.3, 131.8, and 313.3 nM, respectively).³This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321]

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