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VEGFR Tyrosine Kinase Inhibitor II
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VEGFR Tyrosine Kinase Inhibitor II图片
CAS NO:269390-69-4
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
VEGFR Tyrosine Kinase Inhibitor II (compound 3) 是一种有效的血管生成抑制剂，IC50 分别为 0.02、0.18、0.24、7.3 和 7 μ；M 分别用于 KDR、Flt-1、c-Kit、EGF-R 和 c-Src .
Cas No.269390-69-4
化学名N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]-benzamide
Canonical SMILESClC1=CC=C(NC(C2=CC=CC=C2NCC3=CC=NC=C3)=O)C=C1
分子式C19H16ClN3O
分子量337.8
溶解度≤25mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).1 It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 μM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 μM).1 VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.[1]

Reference:
[1] Furet, P., Bold, G., Hofmann, F., et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorganic & Medicinal Chemistry Letters 13(18), 2967-2971 (2003).